Clinical Practice Guidelines create a blueprint for excellence by establishing a comprehensive foundation for gold-standard palliative care for all people living with serious illness, regardless of their diagnosis, prognosis, age or setting. The NCP Guidelines expand on the eight domains of palliative care in the 3rd edition and include clinical and organizational strategies, screening and assessment elements, practice examples, tools and resources. The NCP Guidelines were developed by 17 national organizations who provided representatives to serve on the steering committee and writing workgroup. Over 90 national organizations have endorsed/supported the 4th edition.